The use of HRT carries risks which need to be considered when deciding whether to start taking it, or whether to carry on taking it. For more information on these risks, see the package leaflet.
Do not use this medicine if:
- You have or have ever had breast cancer, or if you are suspected of having it.
- You have cancer which is sensitive to oestrogens, such as cancer of the womb lining (endometrium), or if you are suspected of having it.
- You have any unexplained vaginal bleeding.
- You have excessive thickening of the womb lining (endometrial hyperplasia) that is not being treated.
- You have or have ever had a blood clot in a vein (thrombosis), such as in the legs (deep venous thrombosis) or the lungs (pulmonary embolism).
- You have a blood clotting disorder (such as protein C, protein S, or antithrombin deficiency).
- You have or recently have had a disease caused by blood clots in the arteries , such as a heart attack, stroke or angina.
- You have or ever had a liver disease and your liver function tests have not returned to normal.
- You have a rare blood problem called porphyria which is passed down in families (inherited).
- You are allergic (hypersensitive) to estriol or any of the other ingredients of this medicine (listed in the section ‘What Estriol contains’).
If any of the above conditions appear for the first time while using this medicine, stop taking it at once and consult your doctor immediately.
Warnings and precautions
Tell your doctor if you have ever had any of the following problems, before you start the treatment, as these may return or become worse during treatment with this medicine. If so, you should see your doctor more often for check-ups:
- Fibroids inside your womb.
- Growth of womb lining outside your womb (endometriosis) or a history of excessive growth of the womb lining (endometrial hyperplasia).
- Increased risk of developing blood clots (see the package leaflet for more information).
- Increased risk of getting an oestrogen-sensitive cancer (such as having a mother, sister or grandmother who has had breast cancer).
- High blood pressure.
- A liver disorder, such as a benign liver tumour.
- Diabetes.
- Gallstones.
- Migraine or severe headaches.
- A disease of the immune system that affects many organs of the body (systemic lupus erythematosus, SLE).
- Epilepsy.
- Asthma.
- A disease affecting the eardrum and hearing (otosclerosis).
- Fluid retention due to cardiac or kidney problems.
- Hereditary and acquired angioedema.
Note: This list is not exhaustive. Please refer to the package leaflet for a complete list of warnings and precautions associated with the use of this medicine.
Pregnancy and breastfeeding
This is for use in postmenopausal women only. If you become pregnant, stop taking this medicine and contact your doctor. Please refer to the package leaflet for more information.
Other medicines and Estriol
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines obtained without a prescription, herbal medicines or other natural products. This is because this medicine can affect the way some other medicines work. Also some other medicines can affect the way this medicine works.
For a list of these medicines, please see the package leaflet. Your doctor will have a list of medicines that you should avoid mixing Estriol with.
