Mounjaro versus Wegovy: the differences

How does Mounjaro work?

Mounjaro is an injectable medicine containing the active ingredient tirzepatide. This compound mimics the effects of GLP-1 hormones and GIP hormones from the gut. The first hormone helps you feel full more quickly, stay full for longer, and reduces hunger. The GIP hormone helps to regulate blood sugar levels. The best results are achieved when combined with a balanced diet and regular physical activity. 

How does Wegovy work?

The active ingredient in Wegovy is semaglutide. This medicine is also given by injection. It is intended for people who are overweight or living with obesity, in combination with weight-related conditions such as type 2 diabetes or high blood pressure. This medicine also works best when combined with a healthy diet and an exercise plan. 

How do Mounjaro and Wegovy differ?

Both medicines can be used for weight loss. Some studies indicate that Mounjaro may be slightly more effective than Wegovy, mainly due to the combination of hormones. On the other hand, Wegovy appears to work a little faster than Mounjaro. After 72 weeks, people lost up to 20.2% of their starting weight with the highest dose of Mounjaro, compared to 13.7% with Wegovy. 

Differences and similarities between Mounjaro and Wegovy

Administration

Both medicines must be injected into the abdomen, upper arm, or thigh. It is preferable to do this on the same day each week. Treatment starts with a lower dose, which is increased every 4 weeks. Typically, Wegovy reaches its maximum dose after 17 weeks and Mounjaro after 21 weeks. Depending on individual circumstances and to minimise possible side effects, the schedule may be adjusted. 

Side effects

Like all medicines, Mounjaro and Wegovy may cause side effects. Not everyone will experience all side effects, and this list is not exhaustive. For a complete overview of side effects, refer to the patient information leaflet. Side effects can range from mild to severe and may include: 

When not to use?

Mounjaro and Wegovy are not suitable for everyone. In certain situations, use is not recommended. Do not use these medicines, or consult a doctor before use, if you: 

• Are taking other weight loss products 
• Have severe heart failure 
• Have severely impaired liver or kidney function 
• Have serious stomach or bowel problems 
• Have previously had pancreatitis 
• Have eye problems, such as diabetic retinopathy (damage to the retina caused by diabetes) 

Conclusion

Are you overweight or living with obesity? If lifestyle changes and diet are not enough to achieve weight loss, medication may be an option. Both Mounjaro and Wegovy are effective for weight loss, with Mounjaro showing slightly better results than Wegovy in studies. Which medicine is most suitable for you depends on your circumstances and medical history. With the online decision aid from Dokteronline, you can find out what suits you best. You indicate your preferences and one of our partner doctors will review your request.